Mammalian target of rapamycin inhibition decreases angiotensin II-induced steroidogenesis in HAC15 human adrenocortical carcinoma cells

Y Ali, EP Gomez-Sanchez, CE Gomez-Sanchez - Endocrinology, 2023 - academic.oup.com
HAC15 cells and the parent cell line H295R are the only … regulation of cell survival,
differentiation, proliferation, and metabolism. … of excessive adrenal cortical steroid production due …

The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role

PE Vanderriele, B Caroccia, TM Seccia… - Clinical …, 2018 - portlandpress.com
… In steroid-producing NCI-H295R and HAC15 cell lines, and in APA … hormone in the
adrenocortical zona glomerulosa [1,2] is tightly controlled by multiple factors, as angiotensin II (Ang …

Adrenomedullin: new inhibitory regulator for cortisol synthesis and secretion

S Travers, L Martinerie, QY Xue, J Perrot… - Journal of …, 2021 - joe.bioscientifica.com
… and two human adrenocortical cell lines (H295R and HAC15 cells). … steroid production or
secretion and ADM by studying steroid … 10 mM (K10), and angiotensin II 1 µM (Ang II) for 3 h for …

[PDF][PDF] Renin and prorenin have no direct effect on aldosterone synthesis in the human adrenocortical cell lines H295R and HAC15

J Hofland, A van den Meiracker, FH de Jong - academia.edu
… with that of angiotensin II in two (P)RR-expressing human … ERK phosphorylation nor directly
affect steroid production via this … The cells metabolized Ang I to the same degree without or …

Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition

K Itcho, K Oki, K Kobuke, H Ohno, M Yoneda… - The Journal of Steroid …, 2019 - Elsevier
… the MAS receptor in human adrenocortical carcinoma (HAC15) cells, and clarify … by Ang 1-7
and conditioned medium after A-II is metabolized in HAC15 cells. … Cell culture and materials …

Adropin stimulates proliferation and inhibits adrenocortical steroidogenesis in the human adrenal carcinoma (HAC15) cell line

E Stelcer, P Milecka, H Komarowska, K Jopek… - Frontiers in …, 2020 - frontiersin.org
… pathways involved in glucose and lipid metabolism in mammalian cell lines (34, 35). … -induced
steroid 11β-hydroxylase activity and CYP11B1 mRNA levels, as well as angiotensin II-…

Adrenal corticosteroid perturbation by the endocrine disruptor BDE-47 in a human adrenocortical cell line and male rats

BM Dungar, CD Schupbach, JR Jacobson… - …, 2021 - academic.oup.com
… in corticosteroid synthesis and mitochondrial metabolism … % ddH 2 O) for basal steroidogenesis,
or angiotensin II (Ang II) … our observations in the HAC15 cell line, we performed a study …

VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production

YY Tsai, WE Rainey, MH Johnson, WB Bollag - Molecular and cellular …, 2016 - Elsevier
… in human adrenocortical carcinoma (HAC15) cells that submaximal concentrations of angiotensin
II and VLDL stimulate aldosterone production … with or without metabolic syndrome with …

Aldosterone and cortisol synthesis regulation by angiotensin-(1-7) and angiotensin-converting enzyme 2 in the human adrenal cortex

B Caroccia, PE Vanderriele, TM Seccia… - Journal of …, 2021 - journals.lww.com
… presence of 10 −7 mol/l angiotensin II (Ang II) (panel b) (n = 5 … In a functional metabolic in-vitro
assay, we could measure … of HAC15 with Ang II, based on the assumption that cells would …

Endoplasmic reticulum chaperone calmegin is upregulated in aldosterone-producing adenoma and associates with aldosterone production

K Itcho, K Oki, CE Gomez-Sanchez… - …, 2020 - Am Heart Assoc
metabolism was the most enriched pathway in CLGN-overexpressing … Effect of Ang II (angiotensin
II), forskolin, and KCNJ5 mutation in human adrenocortical carcinoma (HAC15) cells, …